Pharos3D for 3D-analogue search via 3D-shape and pharmacophore configuration, and Hyperspace Search for precise substructure search and structure similarity can both now search 100 trillion-compound spaces - exhaustively and efficiently.
The Alipheron Search Platform for ultra-large combinatorial spaces is peaking towards the next unspoken summit. Explore the currently searchable spaces, and imagine, ten 100-trillion spaces, make a quadrillion compounds searchable for drug discovery.