We are excited to announce that Alipheron will be attending the 5th Alpine Winter Conference on Medicinal and Synthetic Chemistry in St. Anton, Austria from January 25-29, 2026.
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𝐏𝐫𝐞𝐜𝐢𝐬𝐢𝐨𝐧 𝐂𝐨𝐧𝐬𝐭𝐫𝐚𝐢𝐧𝐭𝐬 𝐢𝐧 𝐕𝐢𝐫𝐭𝐮𝐚𝐥 𝐒𝐜𝐫𝐞𝐞𝐧𝐢𝐧𝐠 𝐭𝐨 𝐒𝐨𝐥𝐯𝐞 𝐟𝐨𝐫 𝐂𝐨𝐯𝐚𝐥𝐞𝐧𝐭 𝐚𝐧𝐝 𝐏𝐫𝐨𝐱𝐢𝐦𝐢𝐭𝐲-𝐈𝐧𝐝𝐮𝐜𝐞𝐝 𝐄𝐧𝐯𝐢𝐫𝐨𝐧𝐦𝐞𝐧𝐭𝐬
In the design of covalent inhibitors and bifunctional molecules (PROTACs/Glues), the geometric relationship between a fixed “warhead” or “anchor” and the rest of the scaffold is a primary determinant of success. Traditional virtual screening often struggles to balance these rigid structural requirements with the need for conformational flexibility.
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As we look back on 2025, Drug Discovery hit two major walls.
First, the “Scale Wall”: You had one workflow for small, off-the-shelf catalogs and a completely different, heavier pipeline for ultra-large spaces. Second, the “Modality Wall”: Standard tools struggled to handle the specific requirements of covalent binders, glues, and PROTACs without massive manual intervention.
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𝗦𝘁𝗿𝘂𝗴𝗴𝗹𝗶𝗻𝗴 𝘁𝗼 𝗺𝗮𝗸𝗲 𝘀𝗲𝗻𝘀𝗲 𝗼𝗳 𝘁𝗵𝗼𝘂𝘀𝗮𝗻𝗱𝘀 𝗼𝗳 𝗵𝗶𝗴𝗵-𝘁𝗵𝗿𝗼𝘂𝗴𝗵𝗽𝘂𝘁 𝗵𝗶𝘁𝘀? 🧬
Analyzing Ultra-Large Combinatorial Libraries (ULCLs) or DNA-encoded library (DEL) results require more than just standard search tools. It requires a topological approach.
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