As we look back on 2025, Drug Discovery hit two major walls.
First, the “Scale Wall”: You had one workflow for small, off-the-shelf catalogs and a completely different, heavier pipeline for ultra-large spaces. Second, the “Modality Wall”: Standard tools struggled to handle the specific requirements of covalent binders, glues, and PROTACs without massive manual intervention.
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𝗦𝘁𝗿𝘂𝗴𝗴𝗹𝗶𝗻𝗴 𝘁𝗼 𝗺𝗮𝗸𝗲 𝘀𝗲𝗻𝘀𝗲 𝗼𝗳 𝘁𝗵𝗼𝘂𝘀𝗮𝗻𝗱𝘀 𝗼𝗳 𝗵𝗶𝗴𝗵-𝘁𝗵𝗿𝗼𝘂𝗴𝗵𝗽𝘂𝘁 𝗵𝗶𝘁𝘀? 🧬
Analyzing Ultra-Large Combinatorial Libraries (ULCLs) or DNA-encoded library (DEL) results require more than just standard search tools. It requires a topological approach.
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Life Chemicals and Alipheron have cooperated to construct a novel ultra-large combinatorial library. LifeCheMyriads Space contains 26.7 billion make-on-demand compounds and is now available on the Alipheron Virtual Screening Platform.
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Happy 10-Year Anniversary leadXpro AG!
We celebrated this occasion with a wonderful two-day symposium at PSI in Villigen, Switzerland on 27-28 October 2025.
Together with its incredible collaborators, the boundaries of drug discovery are definitely being pushed at leadXpro AG.
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